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Laryngeal Biomechanics

Peer-Reviewed Journal Articles



  • Acoustics and Aerodynamic Effects Following Glottal and Infraglottal Medialization in an Excised Larynx Model. Oren, L., Maddox, A., Farbos de Luzan, C., Xie C., Howell, R., Dion G., Gutmark, E., Khosla, S. European Archives of Oto-Rhino-Laryngology. DOI: 10.1007/s00405-024-08519-x


  • The Effect of an Increasing Subglottal Stenosis Constriction that extends from the Vocal Folds to the Inferior Border of the Cricoid Cartilage. Michaud-Dorko J., Sundström E., Farbos de Luzan C., Gutmark E., Oren L.  J. of Biomechanical Engineering. PMID: 37943109  |  DOI: 10.1115/1.4064029

  • The Effects of Negative Pressure Induced by Flow Separation Vortices on Vocal Fold Dynamics during Voice Production Jiang W., Zheng X., Farbos de Luzan C., Oren L., Gutmark E., Xue Q.  Bioengineering. PMID: 37892945  |  PMCID: 0604472 | DOI: 10.3390/bioengineering10101215

  • How Face Masks Affect Acoustic and Auditory Perceptual Characteristics of the Singing Voice. Oren L., Rollins M., Gutmark E., Howell R. J. of Voice. PMID: 33775469  | DOI: 10.1016/j.jvoice.2021.02.028

  • An Ex-Vivo Model Examining Acoustics and Aerodynamic Effects Following Medialization with and without Arytenoid Adduction. Maddox A., Oren L., Farbos de Luzan C., Howell R., Gutmark E., Khosla S.  Laryngoscope. PMID: 35655422 | PMCID: 9715814 | DOI: 10.1002/lary.30235

  • Speaker-independent Speech Inversion for Estimation of Nasalance. Siriwardena Y.M., Espy-Wilson C., Boyce S., Tiede M.K., Oren L. arXiv. DOI: 10.48550/arXiv.2306.00203


  • Computational Modeling of Nasal Drug Delivery Using Different Intranasal Corticosteroid Sprays for the Treatment of Eustachian Tube Dysfunction. Sundström E., Talat R., Sedaghat A.R., Khosla S., Oren L. J. Eng. Sci. Med. Diagn. Ther.​  PMID: 35832121  | PMCID: 8996241 | DOI: 10.1115/1.4053907

  • Surgical Treatment of Acquired Velopharyngeal Insufficiency in Adults With Dysphagia and Dysphonia. Lynch C., Rule D., Klaben B., Oren L., Friedman A., Khosla S., Howell R. J. of Voice. PMID: 35027239 | DOI: 10.1016/j.jvoice.2021.12.003

  • Acoustic Screening of the "Wet voice": Proof of Concept in an ex vivo Canine Laryngeal Model.  Rameau A., Andreadis K., Ganesan V., Lachs MS., Rosen T., Wang F., Maddox A., Klinck H., Khosla S., Farbos de Luzan C., Madhusudhana S. Laryngoscope. PMID: 36533566 | PMCID: 10277308 | DOI: 10.1002/lary.30525

  • Fluid-Structure Interaction Analysis of Aerodynamic and Elasticity Forces During Vocal Fold Vibration. Sundström E., Oren L., Farbos de Luzan C., Gutmark E., Khosla S. J. of Voice. PMID: 36180275 | PMCID: 10040475 | DOI: 10.1016/j.jvoice.2022.08.030


  • Change in Aeroacoustic Sound Mechanism During Sibilant Sound With Different Velopharyngeal Opening SizesSundström E., Oren L. Med. Biol. Eng. Comput. PMID: 33797695 | PMCID: 9152924 | DOI: 10.1007/s11517-021-02356-4

  • Evaluating the biomechanical characteristics of cuffed-tracheostomy tubes using finite element analysis. Subramaniam D., Oren L., Willging J., Gutmark E. Comput. Meth. Biomech. Biomed. Engin. PMID: 33761806 | DOI: 10.1080/10255842.2021.1902511

  • Computational Modeling of Voice Production Using Excised Canine Larynx. Jiang W., Farbos de Luzan C., Wang X., Oren L., Khosla S., Xue Q., Zheng X.  J. of Biomechanical Engineering. PMID: 34423809 | PMCID: 8547019 | DOI: 10.1115/1.4052226

  • Quantification of the Intraglottal Pressure Induced by Flow Separation Vortices Using Large Eddy Simulation. Farbos de Luzan C., Oren L., Gutmark E., Khosla S. J. of Voice. PMID: 32273211 | PMCID: 7541566 | DOI: 10.1016/j.jvoice.2020.02.013

  • Effects of False Vocal Folds on Intraglottal Velocity Fields. Oren, L., Khosla, S., Farbos de Luzan, C., Gutmark, E. J. of Voice. PMID: 32147314 | PMCID: 7483598 | DOI: 10.1016/j.jvoice.2020.02.001

  • Predicting critical closing pressure in children with obstructive sleep apnea using fluid-structure interaction. Mylavarapu, G., Gutmark, E., Shott, S., Fleck, R., Mahmoud, M., McConnell, K., ... & Amin, R. Journal of Applied Physiology. PMID: 34528458 | PMCID: PMC8616603 | DOI: 10.1152/japplphysiol.00694.2020




  • Volume Velocity in a Canine Larynx Model Using Time-Resolved Tomographic Particle Image Velocimetry. Farbos de Luzan C., Oren L., Maddox A., Gutmark E., Khosla, S. Experiments in Fluids. PMID: 33664550 | PMCID: 7928205 | DOI: 10.1007/s00348-020-2896-x

  • Impact of Vertical Stiffness Gradient on the Maximum Divergence Angle. Farbos de Luzan, C., Maddox, A., Oren, L., Gutmark, E., Howell, R., Khosla, S. Laryngoscope. PMID: 33382114 | PMCID: 10029808 | DOI: 10.1002/lary.29345


  • Sound Production Mechanisms of Audible Nasal Emission During the Sibilant /s/. Sundström E. & Oren L. J. Acoust. Soc. Am. PMID: 31893718 | PMCID: 7043896 | PMCID: 7043896

  • Understanding Nasal Emission During Speech Production: A Review of Types, Terminology, and Causality. Oren L., Kummer A., & Boyce S. Cleft Palate-Cran. J. PMID: 31262198 | PMCID: 9153061 | DOI: 10.1177/1055665619858873

  • Endoscopic Posterior Cricoid Reduction: A Surgical Method to Improve Posterior Glottic Diastasis. de Alarcón A., Zacharias S., Oren L., Farbos de Luzan C., Tabangin ME., Cohen AP., Roetting NJ. & Fleck RJ. Laryngoscope. PMID: 30887529 | PMCID: 6542651 | DOI: 10.1002/lary.27833

  • How Design Characteristics of Tracheostomy Tubes Affect the Cannula and Tracheal Flows. Subramaniam D., Willging J., Gutmark E., Oren L. Laryngoscope. PMID: 30325519 | DOI: 10.1002/lary.27569

  • Using High-Speed Nasopharyngoscopy to Quantify the Bubbling Above the Velopharyngeal Valve in Cases of Nasal Rustle. Oren L., Rollins M., Padakanti S., Kummer A., Gutmark E., & Boyce S. Cleft Palate-Cran. J. PMID: 31867995 | PMCID: 9175873 | DOI: 10.1177/1055665619894183

  • Pharyngeal Flow Simulations During Sibilant Sound in a Patient-Specific Model with Velopharyngeal Insufficiency. Sundström E., Oren L. J. Acoust. Soc. Am. PMID: 31153316 | PMCID: 6542651 | PMCID: 6542651

  • Measuring Inhalational Glottal Opening to Evaluate Surgical Outcomes in Adult-onset Laryngomalacia: A Novel Method for a Rare Entity. Harvey E. A., Farbos de Luzan C., Sarber K. M., Khosla S., Howell R. Am. J. of Otolaryngology and Head and Neck Surgery. 


  • Preliminary Assessment of Dynamic Voice CT in Post-Airway Reconstruction Patients. Bergeron M., Fleck R., Middlebrook C., Zacharias S., Tolson S., Oren L., Smith D., de Alarcon A. Otolaryngol Head Neck Surg. PMID: 29712504 | DOI: 10.1177/0194599818767628

  • Biomechanics of the soft-palate in sleep apnea patients with polycystic ovarian syndrome. Subramaniam D., Arens R., Wagshul M., Sin S., Wootton D., Gutmark E. Journal of Biomechanics. PMID: 29793766 | PMCID: PMC6062481 | DOI: 10.1016/j.jbiomech.2018.05.013



  • Effect of airflow and material models on tissue displacement for surgical planning of pharyngeal airways in pediatric down syndrome patients. Subramaniam D., Mylavarapu G., Fleck R., Amin R., Shott S., Gutmark E. Journal of the mechanical behavior of biomedical materials. PMID: 28292706 | DOI: 10.1016/j.jmbbm.2017.03.007


  • Effect of Vocal Fold Asymmetries on Glottal Flow. Oren L., Khosla S., Gutmark E. Laryngoscope. PMID: 26972976 | PMCID: 7903440 | DOI: 10.1002/lary.25948

  • Computational modeling of airway obstruction in sleep apnea in Down syndrome: a feasibility study. Mylavarapu G., Subramaniam D., Jonnagiri R., Gutmark E., Fleck R., Amin R., ... Shott S. Otolaryngology--Head and Neck Surgery. PMID: 27048669 | PMCID: PMC588636 | DOI: 10.1177/0194599816639544

  • Upper airway elasticity estimation in pediatric Down syndrome sleep apnea patients using collapsible tube theory. Subramaniam D., Mylavarapu G., McConnell K., Fleck R., Shott S., Amin R., Gutmark E. Annals of biomedical engineering PMID: 26314989 | PMCID: PMC5892827 | DOI: 10.1007/s10439-015-1430-4

  • Compliance measurements of the upper airway in pediatric Down syndrome sleep apnea patients. Subramaniam D., Mylavarapu G., McConnell K., Fleck R., Shott S., Amin R., Gutmark E. Annals of biomedical engineering PMID: 26215306 | PMCID: PMC4731320 | DOI: 10.1007/s10439-015-1392-6



  • Comparison of Glottal Flow Rate Characteristics Based on Experimental and Computational Data. Oren L., Khosla S., Gutmark E. J. Acoust. Soc. Am. PMID: 26520324 | DOI: 10.1121/1.4932022

  • Computational Study of False Vocal Folds Effects on Unsteady Airflows Through Static Models of the Human Larynx. Farbos de Luzan C., Chen J., Mihaescu M., Khosla S.M., Gutmark E. J. of Biomechanics. PMID: 25835787 | PMCID: 4770808 | DOI: 10.1016/j.jbiomech.2015.03.010

  • Intraglottal Velocity and Pressure Measurements in a Hemilarynx Model.  Oren L., Gutmark E. Khosla S. J. Acoust. Soc. Am. PMID: 25698025 | DOI: 10.1121/1.4906833



  • Direct Measurement of Planar Flow Rate in Excised Canine Larynx Model.  Oren L., Khosla S.M., Ying J, Gutmark E. Laryngoscope. PMID: 25093928 | PMCID: 4336254 | DOI: 10.1002/lary.24866   

  • Intraglottal Pressure Distribution Computed from Empirical Velocity Data in Canine Larynx. Oren L., Khosla S.M., Gutmark E.  J. of Biomechanics. PMID: 24636531 | PMCID: 4083398 | DOI: 10.1016/j.jbiomech.2014.02.023    

  • Characterization of the Vocal Fold Vertical Stiffness in a Canine Model. Oren L., Debimski D, Gutmark E., Khosla S.M. J. Voice. PMID: 24495431 | PMCID: 4004683 |  DOI: 10.1016/j.jvoice.2013.11.001

  • Biomechanical Measurements of Vocal Fold Elasticity. Dembinski D., Oren L., Gutmark E., Khosla S. OA Tissue Eng.

  • Intraglottal Geometry and Velocity Measurements in Canine Larynges. Oren L., Debimski D, Gutmark E., Khosla S.M. J. Acoust. Soc. Am. PMID: 24437778 | PMCID: 3985872 | DOI: 10.1121/1.4837222


  • Direct Simultaneous Measurement of Intraglottal Geometry and Velocity Fields in Excised Larynges. Khosla S.M., Oren L., Ying J, Gutmark E. Laryngoscope. PMID: 24510612 | DOI: 10.1002/lary.24512 



  • Acoustic Characteristics of Phonation in “Wet Voice” Conditions. Murugappan S., Boyce S., Khosla S., Kelchner L., Gutmark E. J. Acoust. Soc. Am. PMID: 20370039 | PMCID: 2865707 | DOI: 10.1121/1.3308478

  • Unsteady Laryngeal Airflow Simulations of the Intra-Glottal Vortical Structures. Mihaescu M., Khosla S., Murugappan S., Gutmark E. J. Acoust. Soc. Am. PMID: 20058989 | PMCID: 2821171 | DOI: 10.1121/1.3271276 

  • How Does the Absence or Presence of Subglottal Medialization Affect Glottal Airflow? Grisel J., Khosla S., Murugappan S., Lakhamraju R., Aubry J., Gutmark E., Huntress G. Ann. Oto. Rhinol. Laryn. PMID: 20860282 | DOI: 10.1177/000348941011900809   


  • Validation of Computational Fluid Dynamics Methodology Used for Human Upper Airway Flow Simulations. Mylavarapu G., Murugappan S., Mihaescu M., Kalra M., Khosla S., Gutmark E. J. of Biomechanics. PMID: 19501360 | DOI: 10.1016/j.jbiomech.2009.03.035

  • Flow Fields and Acoustics in a Unilateral Scarred Vocal Fold Model. Murugappan S., Khosla S., Casper K., Oren L, Gutmark E. Ann. Otol. Rhinol. Laryngol. PMID: 19244963 | DOI: 10.1177/000348940911800108

  • Role of Vortices in Voice Production: Normal Versus Asymmetric Tension. Khosla S., Murugappan S., Paniello R., Ying J., Gutmark E. Ann. Laryngoscope. PMID: 19117305 | DOI: 10.1002/lary.20026

  • Role of Vortices in Voice Production: Normal Versus Asymmetric Tension. Oren L., Khosla S., Murugappan S., King R., Gutmark E.. Ann. Otol. Rhinol. Laryngol. PMID: 19374156 | DOI: 10.1177/000348940911800312



  • Flow-Structure Interaction Effects on a Jet Emanating From a Flexible Nozzle. Murugappan S., Gutmark E., Lakhamraju R., Khosla S. Physics of Fluids. PMID: 19547723 | PMCID: 2698281 | DOI: 10.1063/1.3013634

  • Large Eddy Simulation and Reynolds-Averaged Navier-Stokes Modeling of Flow in a Realistic Pharyngeal Airway Model: An Investigation of Obstructive Sleep Apnea. Mihaescu M., Murugappan S., Kalra M., Khosla S., Gutmark. J. of Biomechanics. PMID: 18514205 | DOI: 10.1016/j.jbiomech.2008.04.013

  • Computational Fluid Dynamics Analysis of Upper Airway Reconstructed from Magnetic Resonance Imaging Data. Mihaescu M., Murugappan S., Gutmark E., Donnelly L., Khosla S., Kalra M. Ann. Otol. Rhinol. Laryngol. PMID: 18478841 | DOI: 10.1177/000348940811700411

  • What Can Vortices Tell Us About Vocal Fold Vibration and Voice Production. Khosla S., Murugappan S., Gutmark E. Curr. Opin. Otolaryngol. Head Neck Surg. PMID: 18475068 | DOI: 10.1097/MOO.0b013e3282ff5fc5

  • Using Particle Imaging Velocimetry to Measure Anterior-Posterior Velocity Gradients in the Excised Canine Larynx Model. Khosla S., Murugappan S., Lakhamraju R., Gutmark E. Ann. Otol. Rhinol. Laryngol. PMID: 18357838 | PMCID: 2586298 | DOI: 10.1177/000348940811700212



  • Vortical Flow Field During Phonation in an Excised Canine Larynx Model. Khosla S., Muruguppan S., Gutmark E., Scherer R. Ann. Otol. Rhinol. Laryngol. PMID: 17419527 | PMCID: 2586301 | DOI: 10.1177/000348940711600310

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